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January 20, 2010

Donor Dopamine Pretreatment and Graft Function After Kidney Transplantation

JAMA. 2010;303(3):230-232. doi:10.1001/jama.2009.1995

To the Editor: Dr Schnuelle and colleagues1 reported a randomized controlled trial to examine the effect of donor dopamine treatment on recipient renal allograft function. The authors concluded that an infusion of dopamine (4 μg/kg/min) in cadaveric donors resulted in a reduced requirement for multiple postoperative dialyses, implying a possible reduction in rates of delayed graft function. This improved function was attributed to the adrenergic effects of dopamine and protective effects on graft endothelial cell oxidative stress and cold preservation injury. However, the use of perioperative dopamine infusions in the recipient population is a potentially confounding variable that was not included in the analysis.

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