To the Editor: Dr Volkow and colleagues1 reported measures of dopamine synaptic markers in a sample of adults with ADHD and in healthy controls. As the authors noted, significantly lower dopamine D2/D3 receptor availability in the hypothalamus of ADHD participants might provide a neurobiological basis for often overlooked associations between ADHD and somatic alterations suggestive of hypothalamic dysfunction, such as sleep/arousal disturbances, obesity/overweight, and abnormal stress responses (via altered hypothalamic-pituitary-adrenal axis).
Cortese S, Castellanos FX. Dopamine Reward Pathway in Adult ADHD. JAMA. 2010;303(3):232-234. doi:10.1001/jama.2009.1999