New findings by Dutch scientists may provide some guidance about which patients at risk for lung cancer (usually related to tobacco smoking) who have indeterminate results from multidetector computed tomography (CT) screening need more aggressive follow-up (van Klaveren RJ et al. N Engl J Med. 2009;361:2221-2229).
In the study, 7557 persons had a baseline CT scan and scans 1 year and 3 years later. Those with an “indeterminate” noncalcified nodule at baseline (50-500 mm3 in volume) had a scan 3 months later to assess its growth. Nodules that did not have a volume-doubling time of 400 days or less were reclassified as negative.
Stephenson J. Lung Cancer Screening. JAMA. 2010;303(3):215. doi:10.1001/jama.2009.1965