To the Editor: In the study by Dr Schuetz and colleagues,1 the outcome of patients with LRTI and treatment guided by an algorithm based on PCT levels was similar to patients treated using internationally accepted guidelines. Major secondary end points were exposure to and prescription rate of antibiotics, which was lower in the PCT-guided group, including in patients with community-acquired pneumonia (CAP). It was concluded that PCT can play an important role in the therapeutic approach of LRTI, and that such an approach may reduce antibiotic use.
Stijnis C, van Nieuwkoop C, van Dissel JT. Procalcitonin-Based Guidelines and Lower Respiratory Tract Infections. JAMA. 2010;303(5):418-420. doi:10.1001/jama.2010.53