[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
February 3, 2010

Diabetic Polyneuropathy and Glucose Control—Reply

JAMA. 2010;303(5):420-421. doi:10.1001/jama.2010.56

In Reply: Dr Finucane rightly questions the relationship between hyperglycemia and the development of diabetic polyneuropathy in patients with type 2 diabetes and whether tight control is truly effective. The 3 RCTs he cites did not show a reduction in the prevalence of the disorder in those whose serum glucose was tightly controlled.

One of the major obstacles in addressing this question is establishing a diagnosis of polyneuropathy (and diabetic polyneuropathy in particular). An expert consensus report1 on the definition of polyneuropathy underscored the difficulty of deciding what actually constitutes a polyneuropathy. But the authors of that report did stress the importance of including several criteria, including nerve conduction studies and possibly epidermal nerve fiber counts, as part of that definition.

First Page Preview View Large
First page PDF preview
First page PDF preview