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Lab Reports
April 2, 2014

Experimental Anticoagulant Free of Bleeding Risk

Author Affiliations

Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(13):1282. doi:10.1001/jama.2014.2892

Current anticoagulant drugs also trigger excessive bleeding, but a new humanized antibody that blocks the enzyme factor XII can prevent thrombosis without this adverse effect (Larsson M et al. Sci Transl Med. 2014;6[222]:222ra17).

Previous research showed that factor XII, which is essential for clot formation, influences thrombosis risk but not bleeding. Scientists have developed factor XII inhibitors, but those have off-target effects that compromise their safety in patients.

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