Advanced glycation end products (AGEs), or glycotoxins, that are present at high levels in the Western diet may contribute to both Alzheimer disease and metabolic syndrome by suppressing the enzyme deacetylase survival factor sirtuin 1 (SIRT1), suggest findings from an international team of scientists (Cai W et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1316013111 [published online February 24, 2014]).
Advanced glycation end products are naturally present in uncooked animal-derived foods, and additional AGEs can form in these foods through grilling, broiling, and other cooking methods..
Hampton T. Clue to Dietary Factors, Dementia, and Metabolic Syndrome. JAMA. 2014;311(13):1282. doi:10.1001/jama.2014.3431