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Letters
February 10, 2010

High Perioperative Oxygen Fraction for Abdominal Surgery and Risk of Surgical Site Infection—Reply

JAMA. 2010;303(6):515. doi:10.1001/jama.2010.91

In Reply: We disagree with the assertion by Drs Yu and Yang that the implementation of our trial protocol1 increased the risk of surgical site infection. Our fluid regimen was designed to ensure normovolemia. Blood loss was replaced 1:1 with colloids, and crystalloids were given, aiming at a postoperative body weight increase less than 1 kg. This strategy was chosen because it has been associated with fewer wound complications2 compared with the aggressive fluid strategy described in the trials by Greif et al3 and Belda et al.4

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