To the Editor: In their cohort study, Dr Correll and colleagues1 reported that first-time use of antipsychotic medications in children was associated with weight gain and adverse effects on serum lipids. Although we do not question the basic findings of the study, we are concerned that selection biases related to baseline weight and race/ethnicity may have influenced the results of this nonrandomized study.
Mangurian C, Fuentes-Afflick E, Newcomer JW. Risks From Antipsychotic Medications in Children and Adolescents. JAMA. 2010;303(8):729-731. doi:10.1001/jama.2010.131