In Reply: Dr Mangurian and colleagues note the importance of racial/ethnic influences on metabolic outcomes in psychiatrically ill patients. Race/ethnicity has been associated with cardiometabolic risk status in the general population and in psychiatric patients,1 including the control of risk factors.2 However, in most randomized controlled trials, members of minority ethnic groups are underrepresented. We acknowledge that in this naturalistic cohort study the choice of specific antipsychotic medications was likely influenced, at least in part, by preexisting metabolic risk factors. Unfortunately, the number of children and adolescents who were antipsychotic-naive in our cohort study was not large enough to allow for meaningful subgroup analysis.
Correll CU, Kane JM, Malhotra AK. Risks From Antipsychotic Medications in Children and Adolescents—Reply. JAMA. 2010;303(8):729-731. doi:10.1001/jama.2010.133