To the Editor: In their large Swedish twin study, Dr Sennerby and colleagues1 reported that diagnosis of cardiovascular disease was associated with an increased risk of subsequent hip fracture, and that identical twins without clinical cardiovascular disease had increased risk for hip fracture if their co-twin had heart failure or stroke. This implies a common genetic basis for cardiovascular disease and osteoporosis, but an explanatory mechanism could be high blood pressure.
Strandberg TE. Cardiovascular Disease, Hypertension, and Risk of Hip Fracture. JAMA. 2010;303(8):731-732. doi:10.1001/jama.2010.135