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March 3, 2010

Prone Positioning in Patients With Acute Respiratory Distress Syndrome—Reply

JAMA. 2010;303(9):832-833. doi:10.1001/jama.2010.184

In Reply: Dr Russell suggests that baseline assessment of gas exchange may have been biased by cardiovascular dysfunction and use of vasoactive agents, affecting patients' enrollment as well as severity stratification in our trial. While this hypothesis is physiologically correct, assessment of cardiovascular status once cardiogenic edema has been excluded is not currently considered in the diagnostic criteria of ARDS.1

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