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March 3, 2010

Omega-3 Fatty Acids for CHD With Depression—Reply

JAMA. 2010;303(9):836. doi:10.1001/jama.2010.191

In Reply: Dr Anghelescu offers 2 possible explanations for why our clinical trial found no difference in depression in patients with CHD after 10 weeks of treatment with a standard antidepressant (sertraline) and either 2 g/d of omega-3 fatty acids or a placebo. First, he notes that our measures of depression severity include somatic symptoms that may be confounded with symptoms of heart disease and that this may have made it more difficult to observe a treatment effect. We chose the HAM-D and the BDI-II because they are widely used measures of depression severity in clinical trials and have been recommended for use in assessing depression in patients with heart disease.1

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