In Reply: Drs Spronk and Schultz note that the mean day 1 tidal volume of 8.3 mL/kg ideal body weight in our study population was slightly higher than might be recommended by the findings of the ARDSNet ARMA trial1 (which targeted a tidal volume of 6 mL/kg ideal body weight), although plateau pressure remained within an acceptable range. There are likely multiple reasons for this.
Fowler RA, Lapinsky SE, Domínguez-Cherit G. Mechanical Ventilation in Critically Ill Patients With 2009 Influenza A(H1N1)—Reply. JAMA. 2010;303(10):939-941. doi:10.1001/jama.2010.199