In Reply: We agree with Drs Saloustros and Mavroudis that some of the increase in breast cancer detection in the United States was secondary to hormone therapy. The abrupt decline in incidence followed by a leveling off between 2002 and 2004 has been shown to correspond to the dramatic decline in hormone therapy prescriptions, independent of mammography.1,2 Screening is not the only factor responsible for the absolute increase in the detection of early breast cancers, but it appears to be a significant contributor.
Esserman L, Thompson I. Screening and Detection of Breast Cancer and Prostate Cancer—Reply. JAMA. 2010;303(11):1032-1034. doi:10.1001/jama.2010.276