To the Editor: In their case-control study, Dr Bodmer and colleagues1 investigated the association between the use of lipid-lowering agents and the risk of incident gallstone disease followed by cholecystectomy. The authors compared patients who had a recorded diagnosis of gallstone disease or gallstone-related complications and had undergone cholecystectomy with matched controls who had no record of gallstones, gallstone-related complications, or cholecystectomy. They concluded that long-term use of statins was associated with a decreased risk of gallstones followed by cholecystectomy. Several issues deserve further discussion.
Hsu C, Kao J. Use of Statins and Gallstone Risk. JAMA. 2010;303(12):1146-1147. doi:10.1001/jama.2010.320