A team of scientists has found that a novel agent is effective against H5N1 avian influenza virus, including oseltamivir-resistant strains (Kiso M et al. PLoS Pathog. 2010;6:e1000786).
The neuraminidase inhibitor R-125489 and its prodrug CS-8958 have previously shown potent activity against seasonal influenza viruses in animal studies. In the new work, scientists from Japan, Vietnam, Indonesia, and the United States found that the neuraminidase activity of both oseltamivir-sensitive and oseltamivir-resistant H5N1 strains was reduced in vitro by CS-8958.
Hampton T. Fighting H5N1 Avian Flu. JAMA. 2010;303(13):1245. doi:10.1001/jama.2010.349