To the Editor: The Ginkgo Evaluation of Memory (GEM) study by Dr Snitz and colleagues1 provided empirical evidence in a randomized controlled trial that treatment with Ginkgo biloba does not slow the rate of cognitive decline in older adults. Through examination of the effect modification by baseline cognitive status (mild cognitive impairment [MCI] vs normal cognition), the authors concluded that G biloba affected neither cognitive changes associated with dementia prodrome nor cognitive changes associated with normal aging.
Feng L. Ginkgo biloba and Cognitive Decline. JAMA. 2010;303(15):1477-1478. doi:10.1001/jama.2010.434