To the Editor: Based on a subpopulation of the Framingham cohort, Dr Lieb and colleagues1 suggested that higher levels of leptin are associated with reduced incidence of dementia and Alzheimer disease (AD), correlated with positive associations between leptin levels and total brain and hippocampal volumes. We believe that caution is needed in the interpretation of those results.
Paz-Filho G, Wong M, Licinio J. Leptin Levels and Alzheimer Disease. JAMA. 2010;303(15):1478-1479. doi:10.1001/jama.2010.436