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Letters
April 28, 2010

Depression Severity and Effect of Antidepressant Medications

JAMA. 2010;303(16):1596-1599. doi:10.1001/jama.2010.505

To the Editor: Mr Fournier and colleagues1 conducted a patient-level meta-analysis of the magnitude of benefit of antidepressant medications compared with placebo. They concluded that the size of the benefit of active treatment increases with the severity of depression and may be nonexistent in patients with mild or moderate symptoms. The authors hypothesized a significant interaction between treatment and effect: that the differences between treatment and placebo would increase as baseline severity increased.

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