To the Editor: We are concerned about several issues in the study by Mr Fournier and colleagues1 that may have compromised the interpretability and generalizability of their findings. First, antidepressants may exert their effects earlier in the course of treatment than previously thought.2 If so, the exclusion of short-term studies (less than 6 weeks) would have significantly minimized the clinical pertinence of their findings that focused on acute phase treatment.
Suzuki T, Uchida H, Nakajima S. Depression Severity and Effect of Antidepressant Medications. JAMA. 2010;303(16):1596-1599. doi:10.1001/jama.2010.507