Author Affiliations: Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Even though sickle cell disease (SCD) is caused by a single-nucleotide mutation (GAT→GTT in the sixth codon of axon 1 of the β globin gene), its clinical presentation involves a multitude of complications involving all organs.1- 3 The manifestations of SCD are recurrent—a painful crisis that is resolved will soon be replaced by a new episode of pain; a leg ulcer that heals may soon return.2
Ballas SK. Neurocognitive Complications of Sickle Cell Anemia in Adults. JAMA. 2010;303(18):1862-1863. doi:10.1001/jama.2010.610