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May 12, 2010

Neurocognitive Complications of Sickle Cell Anemia in Adults

Author Affiliations

Author Affiliations: Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

JAMA. 2010;303(18):1862-1863. doi:10.1001/jama.2010.610

Even though sickle cell disease (SCD) is caused by a single-nucleotide mutation (GAT→GTT in the sixth codon of axon 1 of the β globin gene), its clinical presentation involves a multitude of complications involving all organs.13 The manifestations of SCD are recurrent—a painful crisis that is resolved will soon be replaced by a new episode of pain; a leg ulcer that heals may soon return.2

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