In Reply: In response to Dr Holm and colleagues, we modeled a combined end point of CAD and stroke because this is the clinically relevant end point for risk prediction as used in the updated Framingham Heart Score.1 However, we explored removing the 2 SNPs that were associated with stroke from the 12 SNP score and limiting the outcome to CAD and again found no added predictive ability beyond the traditional risk factors. We also note that family history of MI was predictive for CVD, despite the inclusion of stroke.
Paynter NP, Chasman DI, Ridker PM. Genetic Risk Score and Cardiovascular Events in Women—Reply. JAMA. 2010;303(20):2032-2033. doi:10.1001/jama.2010.661