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Lab Reports
June 2, 2010

Parkinson Disease Insights

JAMA. 2010;303(21):2129. doi:10.1001/jama.2010.685

A study in cultured cells by scientists in Japan and the United States provides new information on interactions between 2 genes known to be involved in the development of familial forms of Parkinson disease (Matsuda N et al. J Cell Biol. 2010;189[2]:211-221).

One gene encodes parkin, which adds ubiquitin molecules to other proteins to trigger their degradation; the second gene, PINK1 (PTEN-induced putative kinase 1), is involved with mitochondrial maintenance. Problems with ubiquitination and mitochondrial integrity are key factors in the pathogenesis of Parkinson disease.

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