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June 16, 2010

Stereotactic Body Radiation Therapy for Inoperable Lung Cancer

JAMA. 2010;303(23):2354-2355. doi:10.1001/jama.2010.777

To the Editor: In their phase 2 clinical trial (Radiation Therapy Oncology Group [RTOG] 0236), Dr Timmerman and colleagues1 demonstrated excellent locoregional tumor control for medically inoperable stage I non–small cell lung cancer and the feasibility of delivering stereotactic body radiation therapy (SBRT) in a cooperative group setting. Among their findings was a low rate of regional nodal failure (2/55, 3.6%) despite using exclusively noninvasive mediastinal staging. The observed rates of regional recurrence with SBRT compare favorably with those observed with wedge resection and are comparable with lobectomy with invasive mediastinal staging.2

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