In Reply: Drs Small and Morris hypothesize that the lack of significant differences in serological infection rates between study groups may not have existed had we used LAIV. We agree that this is a possibility, particularly given the number of studies showing indirect benefits with live vaccine.1- 3 We sought to test the effect of inactivated vaccine given its more widespread use and the relative lack of randomized trials evaluating it for indirect benefit.
Loeb M, Russell M, Earn DJD. Influenza Vaccination of Children and Infection Rates in the Community—Reply. JAMA. 2010;303(23):2355-2356. doi:10.1001/jama.2010.780