To the Editor: In their study of anemia management in dialysis patients, Dr Brookhart and colleagues1 reported that intravenous (IV) iron may have important toxic effects. They mentioned that IV iron may have a theoretical risk of sepsis and infection and increase the risk of cardiovascular disease. However, they did not cite a prospective study in 985 dialysis patients receiving IV iron as part of the regimen for dialysis-associated anemia,2 which did not find an association between infection risk and ferritin levels or total dose of IV iron administration (although infection risk was associated with central venous catheters, history of bacteremia, arteriovenous grafts, and immunosuppression).
Auerbach M. Anemia Management and Mortality Risk in Incident Hemodialysis Patients. JAMA. 2010;304(1):41-43. doi:10.1001/jama.2010.890