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Medical News and Perspectives
July 7, 2010

Proton Pump Inhibitors Linked to Fracture Risk

JAMA. 2010;304(1):29. doi:10.1001/jama.2010.862

Revised labeling for prescription and over-the-counter proton pump inhibitors (PPIs) will warn that these stomach acid–reducing medications could increase patients' risk of hip, wrist, and spine fractures, US health authorities announced.

“When prescribing proton pump inhibitors, health professionals should consider whether a lower dose or shorter duration of therapy would adequately treat the patient's condition,” said Joyce Korvick, MD, deputy director for safety in the US Food and Drug Administration's (FDA’s) Division of Gastroenterology Products.

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