In view of the substantially increasing epidemic of Alzheimer disease (AD), efforts to find and explain genetic, biological, and environmental influences on the risk of AD are essential. The Framingham Heart Study (FHS) is the exemplar of long-term community-based studies and, despite some limitations involving generalizability, provides a rich opportunity for investigation of AD risk factors,1 including peripheral blood biomarkers of risk. The findings of such research can guide therapeutic trials, improving the likelihood of success in finding preventive and disease-slowing interventions.
Aisen PS. Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia. JAMA. 2014;311(16):1684-1685. doi:10.1001/jama.2014.3120