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In Reply As stated in our Viewpoint, the problem of medication nonadherence is often multifactorial, and there is no universal formula that will resolve adherence issues for every patient in every situation. The key is to identify characteristics and situations making patients vulnerable for medication nonadherence and subsequently provide a personalized program to address specific needs in the mode and time that will be most effective to motivate adherence.
We fully agree with Dr Frazee and colleagues that providing enabling strategies to patients so that they can better take ownership of their health, specifically by taking their medications as prescribed, is important to establishing long-term healthy adherence behaviors. Our Viewpoint identified ingredients of interventions that have successfully improved medication adherence (eg, increasing patient knowledge, providing counseling and accountability, enabling patient self-monitoring, and decreasing cost, among others). Although these strategies can be effective in motivating medication adherence, they will not prove unanimously successful. We also acknowledge that other methods (eg, renewal reminders, automated renewals, etc) suggested by Frazee and colleagues could also facilitate improved adherence.
Zullig LL, Peterson ED, Bosworth HB. Strategies to Overcome Medication Nonadherence—Reply. JAMA. 2014;311(16):1693-1694. doi:10.1001/jama.2014.1607