April 23/30, 2014

From JAMA’s Daily News Site

Author Affiliations

Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(16):1600. doi:10.1001/jama.2014.3907

Malnutrition may reduce HIV medication levels in pregnant or breastfeeding women, impeding efforts to prevent mother-to-child transmission.

A recent study involved 225 Ugandan women being treated for HIV infection. About 80% had inadequate food for their families, 50% reported moderate to severe hunger, and 26% lost weight during pregnancy. Researchers found substantially reduced drug levels in malnourished study participants compared with well-nourished participants: a decrease in exposure of 33% for lopinavir, 15% for efavirenz, and 17% for ritonavir. They also found that during pregnancy the body clears lopinavir and ritonavir more quickly, which clinicians account for when dosing pregnant women.

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