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July 14, 2010

Bias and Trials Stopped Early for Benefit

JAMA. 2010;304(2):156-159. doi:10.1001/jama.2010.931

To the Editor: Dr Bassler and colleagues1 claimed that trials stopped for efficacy are prone to major bias. Unfortunately, their conclusions are based on faulty mathematical reasoning.2,3 We believe that they misinterpreted their data and provided incorrect guidance about ethical trial design.

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