In Reply: We agree with several of the points raised by Dr Neligan and colleagues. Many anticonvulsants are used for reasons other than epilepsy, especially gabapentin, whose marketing for off-label purposes resulted in widespread use without approved indication.1 We therefore used 2 different comparison groups to achieve fair comparisons for patients with and without epilepsy. We agree that the drugs' risk-benefit relationships will differ in epilepsy, in which they are a mainstay of therapy, compared with indications for which they are not effective. The short median follow-up resulted from treatment changes and short-term use, which led to censoring. However, we did account for extensive pretreatment data in our multivariate analyses.
Patorno E, Avorn J, Schneeweiss S. Antiepileptic Medications and the Risk of Suicide—Reply. JAMA. 2010;304(5):521-523. doi:10.1001/jama.2010.1069