Use of combination measles-mumps-rubella-varicella (MMRV) vaccine in young children is associated with an increased risk of febrile seizures 7 to 10 days after vaccination compared with separate vaccination with the varicella vaccine and the measles-mumps-rubella (MMR) vaccine, according to a study funded by the Centers for Disease Control and Prevention (CDC).
The scientists analyzed data from the Vaccine Safety Datalink, a surveillance system with data from 8 managed care organizations, on more than 450 000 children from 12 to 23 months of age who received either the MMRV or the MMR plus a separate varicella vaccination (Klein NP et al. Pediatrics. 2010;126:e1-e8). They found 1 additional seizure for every 2300 doses of the MMRV vaccine compared with the two separate vaccines.
Kuehn BM. MMRV and Seizures. JAMA. 2010;304(8):846. doi:10.1001/jama.2010.1198