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Letters
August 25, 2010

Genome-wide Association Study of Genetic Loci and Alzheimer Disease—Reply

JAMA. 2010;304(8):858. doi:10.1001/jama.2010.1173

In Reply: We concur with 2 important points made by Dr Brown and colleagues. First, the power of genetic studies can be increased not only by increasing sample sizes but also by defining a more homogeneous phenotype, such as pathologically confirmed cases or pathological endophenotypes.1,2 Second, GWAS and linkage studies can complement each other; hypotheses generated by one can be tested using the other study design, and the 2 techniques can be combined to improve identification of true loci.3

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