Using dendritic cells (DCs) and T cells isolated from human blood, researchers from Boston University School of Medicine have identified 2 molecules—peroxisome proliferator-activated receptor γ (PPAR-γ) and liver X receptor (LXR)—that, when activated by drugs, can inhibit various aspects of HIV transmission (Hanley TM et al. PLoS Pathog 2010;6:e1000981). These findings have implications for the development of new antiviral microbicides that could block HIV transmission.
Friedrich MJ. Blocking HIV Transmission. JAMA. 2010;304(9):954. doi:10.1001/jama.2010.1220