[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.241.199. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
Lab Reports
September 1, 2010

Regulating Addiction

JAMA. 2010;304(9):954. doi:10.1001/jama.2010.1223

Studies in rats have revealed the key role that a small regulatory piece of RNA, microRNA 212 (miR-212), plays in the brain to regulate cocaine intake. This may provide a novel target for treatment of addictions to cocaine and other drugs (Hollander JA et al. Nature. 2010;466[7303]:197-202).

MicroRNAs are small non–protein-coding RNAs that regulate gene expression. Investigators from the Scripps Research Institute in Jupiter, Fla, showed that cocaine-seeking behavior in rats is modulated by this microRNA; rats that self-administered cocaine for long periods showed increased levels of miR-212 in the brain’s striatum. This increase in miR-212 eventually led to a decrease in cocaine intake in the rats and protected against addictive behavior. Conversely, blocking the production of miR-212 increased cocaine intake in the rodents.

First Page Preview View Large
First page PDF preview
First page PDF preview
×