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Medical News & Perspectives
September 1, 2010

Estrogen Spray Poses Risks to Children, Pets Through Contact With Treated Skin

JAMA. 2010;304(9):953. doi:10.1001/jama.2010.1227

Atopical estrogen spray used to reduce menopause-related hot flashes can cause adverse effects in children and pets inadvertently exposed to the drug through skin contact.

In a safety announcement, the US Food and Drug Administration (FDA) warned that children who are unintentionally exposed to Evamist may undergo premature puberty. Girls may experience nipple swelling and breast enlargement; boys also could develop enlarged breasts. Pets exposed to the drug may experience mammary or nipple enlargement and vulvar swelling.

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