Atopical estrogen spray used to reduce menopause-related hot flashes can cause adverse effects in children and pets inadvertently exposed to the drug through skin contact.
In a safety announcement, the US Food and Drug Administration (FDA) warned that children who are unintentionally exposed to Evamist may undergo premature puberty. Girls may experience nipple swelling and breast enlargement; boys also could develop enlarged breasts. Pets exposed to the drug may experience mammary or nipple enlargement and vulvar swelling.
Voelker R. Estrogen Spray Poses Risks to Children, Pets Through Contact With Treated Skin. JAMA. 2010;304(9):953. doi:10.1001/jama.2010.1227