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JAMA Clinical Challenge
May 7, 2014

A Child With a White Pupil

Author Affiliations
  • 1Department of Ophthalmology, VU University Medical Center, Amsterdam, the Netherlands
JAMA. 2014;311(17):1799-1800. doi:10.1001/jama.2013.286248

A healthy 4-year-old girl presents to the ophthalmologist for evaluation of a white pupil (Figure 1). The parents had noted a white pupillary reflection in the left eye for the past 2 months. On ophthalmologic examination, the visual acuity of the right eye was 6/7.5 (equivalent to 20/25) and the left eye did not follow an object. The remainder of the physical examination was unremarkable. There was no family history of childhood cancers, and the patient did not have any other pertinent or contributory medical history.

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