Knowledge of the developmental effects of antiepileptic drugs (AEDs) is inadequate. The first reports of an association of fetal AED exposure with congenital malformations occurred in the 1960s, and the first report of a specific congenital malformation for a specific AED was published in the early 1980s (ie, cleft lip/palate and valproate). Only recently has the scope of differential fetal AED risks exposure for congenital malformations, cognitive deficits, and behavioral disorders begun to emerge.
Meador KJ. Breastfeeding and Antiepileptic Drugs. JAMA. 2014;311(17):1797-1798. doi:10.1001/jama.2014.967