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Lab Reports
May 7, 2014

Misplaced Protein May Be Drug Target for Kidney Cancer

JAMA. 2014;311(17):1722. doi:10.1001/jama.2014.4757

New research reveals that an environment of low oxygen, or hypoxia, that occurs when kidney cancer cells outgrow their local blood supply may promote tumor growth by causing a nuclear protein called speckle-type POZ protein (SPOP) to become overexpressed and move into the cytoplasm (Li G et al. Cancer Cell. doi:10.1016/j.ccr.2014.02.007 [published online March 20, 2014]). In the nucleus, SPOP normally suppresses tumor proliferation, but in the cytoplasm it encourages it and causes more hypoxia.

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