New research reveals that an environment of low oxygen, or hypoxia, that occurs when kidney cancer cells outgrow their local blood supply may promote tumor growth by causing a nuclear protein called speckle-type POZ protein (SPOP) to become overexpressed and move into the cytoplasm (Li G et al. Cancer Cell. doi:10.1016/j.ccr.2014.02.007 [published online March 20, 2014]). In the nucleus, SPOP normally suppresses tumor proliferation, but in the cytoplasm it encourages it and causes more hypoxia.
Hampton T. Misplaced Protein May Be Drug Target for Kidney Cancer. JAMA. 2014;311(17):1722. doi:10.1001/jama.2014.4757