Views 236
Citations 0
Lab Reports
May 7, 2014

Misplaced Protein May Be Drug Target for Kidney Cancer

Author Affiliations

Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(17):1722. doi:10.1001/jama.2014.4757

New research reveals that an environment of low oxygen, or hypoxia, that occurs when kidney cancer cells outgrow their local blood supply may promote tumor growth by causing a nuclear protein called speckle-type POZ protein (SPOP) to become overexpressed and move into the cytoplasm (Li G et al. Cancer Cell. doi:10.1016/j.ccr.2014.02.007 [published online March 20, 2014]). In the nucleus, SPOP normally suppresses tumor proliferation, but in the cytoplasm it encourages it and causes more hypoxia.

First Page Preview View Large
First page PDF preview
First page PDF preview