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In Reply We agree with Drs Poulton and Nanan that the psychotropic actions of weight-loss medications are potentially of great importance, particularly given that most obesity medications approved or in development affect neurotransmitters that may have an effect on mood, cognition, or behavior. Some of these effects, such as negative mood or irritability, may be problematic, whereas others may potentially enhance ability to adhere to diet and exercise recommendations.
Yanovski SZ, Yanovski JA. Drugs for the Treatment of Obesity—Reply. JAMA. 2014;311(17):1807. doi:10.1001/jama.2014.2110