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news@JAMA
May 7, 2014

From JAMA’s Daily News Site

JAMA. 2014;311(17):1721. doi:10.1001/jama.2014.4252

A high-calorie, high-carbohydrate diet may safely treat amyotrophic lateral sclerosis (ALS), a progressive neurological disorder commonly known as Lou Gehrig disease.

Researchers randomly assigned 20 patients with advanced ALS to a diet for weight maintenance or a high-calorie diet that also was either high in fat or high in carbohydrates. Those on the high-carbohydrate diet had the fewest adverse events: 23 among 8 patients compared with 42 among 6 patients in the weight maintenance group and 48 among 6 patients in the high-fat group. Previous studies have shown that moderately obese patients with ALS lived longer and their disease progressed more slowly than underweight patients.

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