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September 22/29, 2010

Antibiotic Therapy in Patients Hospitalized With Acute Chronic Obstructive Pulmonary Disease

JAMA. 2010;304(12):1325-1327. doi:10.1001/jama.2010.1339

To the Editor: We have a number of concerns about the message to indiscriminately prescribe antibiotics to any hospitalized patient with exacerbation of COPD conveyed in the study by Dr Rothberg and colleagues.1 First, even after propensity matching, significant heterogeneity in comorbidities remained between patients who did and who did not receive antibiotics, indicating residual confounding.

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