In Reply: Dr Ackland and colleagues and Dr Iscoe and colleagues raise important questions regarding the potential mechanisms of injury by which excessive supplemental oxygen administration could be harmful following resuscitation from cardiac arrest. There are important knowledge gaps regarding the administration of supplemental oxygen to patients after resuscitation, and these should be addressed in a systematic fashion before experimental trials are designed to test the efficacy of a controlled reoxygenation strategy (ie, rapid de-escalation of supplemental oxygen after reperfusion).
Trzeciak S, Kilgannon JH, Jones AE. Arterial Hyperoxia and In-Hospital Mortality After Resuscitation From Cardiac Arrest—Reply. JAMA. 2010;304(13):1440-1441. doi:10.1001/jama.2010.1398