In Reply: We agree with Dr Vinnard that higher incidence of subclinical or undiagnosed disease, such as HIV, is a potential explanation for the higher incidence of infection among black patients in our study. Further studies are necessary to determine whether these disparities would be reduced by early diagnosis of chronic diseases and instituting effective preventive strategies.
Yende S, Mayr F, Angus DC. Racial Differences in Rates of Severe Sepsis—Reply. JAMA. 2010;304(14):1556. doi:10.1001/jama.2010.1442