With no cure and a prevalence twice that of Alzheimer disease, age-related macular degeneration (AMD) is increasingly being recognized as a serious condition that leads to vision loss in a growing number of elderly persons. While a clear heritable component to the disease has been known for years, only recently have investigators begun to tease out the alterations in genetic pathways—particularly those involving complement and to some extent cholesterol—that play a role.
Hampton T. Genetic Research Provides Insights Into Age-Related Macular Degeneration. JAMA. 2010;304(14):1541-1543. doi:10.1001/jama.2010.1411