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October 20, 2010

Hypertension Control and Cardiovascular Outcomes Among Patients With Diabetes and Coronary Artery Disease—Reply

JAMA. 2010;304(15):1672-1673. doi:10.1001/jama.2010.1465

In Reply: Drs van Hateren and Bilo inquire about the relationship between age and outcomes in our population of diabetic patients with hypertension and CAD. We recently published another study categorizing all patients from INVEST into 4 groups based on age at baseline (<60, 60-<70, 70-<80 and ≥80 years), and approximately 25% to 30% of patients in each age group had diabetes.1 In that analysis, we observed a progressive increase in risk with increasing age for the primary outcome (first occurrence of all-cause death, nonfatal myocardial infarction, or nonfatal stroke), driven by death, as well as a J-shaped relationship within each age group between the primary outcome and in-treatment systolic and diastolic pressures.1

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