To the Editor: In their randomized placebo-controlled trial, Mr Wilkens and colleagues1 studied the effect of oral glucosamine on pain-related disability in patients with chronic low back pain (LBP). The authors concluded that, in a representative sample of the LBP population presenting in general clinical practice, oral glucosamine did not provide any advantages over placebo for self-administered functional, pain-related, and quality-of-life outcome measures.
Runhaar J, van der Wouden JC. Effect of Oral Glucosamine on Pain-Related Disability in Patients With Chronic Low Back Pain. JAMA. 2010;304(15):1673. doi:10.1001/jama.2010.1466