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Lab Reports
November 3, 2010

Gene Silencing and Vasculitis

JAMA. 2010;304(17):1888. doi:10.1001/jama.2010.1519

Two genes are inappropriately switched on in individuals with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis, suggesting that these genes play a role in development of the disease, report researchers from the University of North Carolina at Chapel Hill (Ciavatta DJ et al. J Clin Invest. 2010:120[9]:3209-3219). In healthy individuals, these 2 genes normally are silenced—that is, prevented from being expressed.

Patients with ANCA vasculitis have 2 aberrantly expressed neutrophil proteins, proteinase 3 (PR3) and myleoperoxidase (MPO). ANCAs activate neutrophils, causing vascular injury that leads to ANCA vasculitis.

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